Biosynthesis of Prodigiosin and Its Applications

Genome-wide screening and identification of factors affecting the biosynthesis of prodigiosin by Hahella chejuensis, using Escherichia coli as a surrogate host.

A marine bacterium, Hahella chejuensis, recently has attracted attention due to its lytic activity against a red-tide dinoflagellate. The algicidal function originates from its red pigment, prodigiosin, which also exhibits immunosuppressive or anticancer activity. Genome sequencing and functional analysis revealed a gene set contained in the hap gene cluster that is responsible for the biosynth...

Efficient recombinant production of prodigiosin in Pseudomonas putida

Serratia marcescens and several other bacteria produce the red-colored pigment prodigiosin which possesses bioactivities as an antimicrobial, anticancer, and immunosuppressive agent. Therefore, there is a great interest to produce this natural compound. Efforts aiming at its biotechnological production have so far largely focused on the original producer and opportunistic human pathogen S. marc...

The biosynthesis of prodigiosin, the tripyrrylmethene pigment from Bacillus prodigiosus (Serratia marcescens).

Inhibitory effect of polymyxin B on prodigiosin biosynthesis in Serratia marcescens.

Sir: Prodigiosin or prodigiosin-like antibiotic pigments are tripyrrole compounds synthesized by Serratia marcescens, Vibrio psychroerythrus, Pseudomonas magnesorubra and Alteromonas rubra as well as several genera of actinomycetes.1.2) Although the structures of several of the pigments are known, the site of localization and biosynthesis is less than clear.3,4) Studies of inhibition of prodigi...

Thiamine-induced formation of the monopyrrole moiety of prodigiosin.

Thiamine stimulates the production of a red pigment, which is chromatographically and spectrophotometrically identical to prodigiosin, by growing cultures of Serratia marcescens mutant 9-3-3. This mutant is blocked in the formation of 2-methyl-3-amylpyrrole (MAP), the monopyrrole moiety of prodigiosin, but accumulates 4-methoxy-2,2,'-bipyrrole-5-carboxaldehyde (MBC) and can couple this compound...